McGill J K, Gallagher L, Carswell H V O, Irving E A, Dominiczak A F, Macrae I M
Division of Clinical Neuroscience, Wellcome Surgical Institute, University of Glasgow, Switchback Road, Glasgow, G61 1QH.
Stroke. 2005 Jan;36(1):135-41. doi: 10.1161/01.STR.0000149629.32525.b7. Epub 2004 Nov 29.
To identify if the stroke-prone spontaneously hypertensive rat (SHRSP) exhibits impaired functional recovery after stroke compared with its normotensive reference strain, the Wistar Kyoto rat (WKY).
In study 1, a 2-mm distal middle cerebral artery occlusion (middle cerebral artery occlusion) was performed in both strains and recovery assessed using a 33-point neurological score. Because SHRSPs displayed much larger infarcts than WKYs, study 2 and study 3 involved extending the length of middle cerebral artery (MCA) occlusion in the WKY to increase the volume and distribution of infarction to comparable levels with SHRSP. Animals were assessed with the neurological score, tapered beam walk, and cylinder tests.
In study 1, infarct volume (expressed as a percent of contralateral hemisphere) was WKY 13.1+/-3% and SHRSP 19.8+/-1%. Initial neurological deficit was greater (WKY 25+/-1, SHRSP 22+/-1, out of a possible 33) and subsequent recovery was poorer in SHRSP. In studies 2 and 3, infarct volume and distribution (study 2, WKY 21.8+/-1.3%, SHRSP 22.9+/-3%; study 3, WKY 17.2+/-2%, SHRSP 16.5+/-3%) and initial neurological deficit at 2 hours after middle cerebral artery occlusion (study 2 WKY 23+/-1, SHRSP 22+/-2; study 3 WKY 25+/-1 and SHRSP 23+/-1; mean+/-SEM) were comparable between strains. However, whereas WKY recovered toward normal scores, SHRSP scored significantly lower 2 weeks (study 2) and 4 weeks (study 3) after middle cerebral artery occlusion. Beam walk data revealed long-term impairment in SHRSP contralateral limb use, compared with WKY, at days 3, 7, and 28 (P<0.05).
SHRSP exhibit impaired functional recovery after stroke compared with WKY.
确定易中风自发性高血压大鼠（SHRSP）与正常血压对照品系Wistar Kyoto大鼠（WKY）相比，中风后功能恢复是否受损。
在研究1中，对两个品系的大鼠均进行2毫米远端大脑中动脉闭塞（大脑中动脉闭塞），并使用33分神经学评分评估恢复情况。由于SHRSP的梗死灶比WKY大得多，研究2和研究3涉及延长WKY大脑中动脉（MCA）闭塞的长度，以增加梗死体积和分布，使其与SHRSP相当。用神经学评分、窄光束行走和圆筒试验对动物进行评估。
在研究1中，梗死体积（以对侧半球的百分比表示）为WKY 13.1±3%，SHRSP 19.8±1%。初始神经功能缺损更大（WKY为25±1，SHRSP为22±1，满分33分），且SHRSP随后的恢复较差。在研究2和研究3中，梗死体积和分布（研究2，WKY为21.8±1.3%，SHRSP为22.9±3%；研究3，WKY为17.2±2%，SHRSP为16.5±3%）以及大脑中动脉闭塞后2小时的初始神经功能缺损（研究2，WKY为23±1，SHRSP为22±2；研究3，WKY为25±1，SHRSP为23±1；平均值±标准误）在两个品系之间相当。然而，尽管WKY恢复到正常评分，但SHRSP在大脑中动脉闭塞后2周（研究2）和4周（研究3）的评分明显更低。窄光束行走数据显示，与WKY相比，SHRSP在第3、7和28天对侧肢体使用存在长期损伤（P<0.05）。
与WKY相比，SHRSP中风后功能恢复受损。
