Khan S, Cleanthis M, Smout J, Flather M, Stansby G
Northern Vascular Unit, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK.
Eur J Vasc Endovasc Surg. 2005 Jan;29(1):2-9. doi: 10.1016/j.ejvs.2004.09.020.
To review the published evidence supporting the use of life-style modification in peripheral arterial disease (PAD).
A systematic search of the medical literature was performed for relevant studies.
The publications obtained were then searched for randomised clinical trials which reported end-points of mortality or major cardiovascular event rates with various life-style modifications.
Only one randomised controlled trial was found reporting relevant end-points. Other trials were of other end-points such as walking distance or biochemical markers.
There is a lack of randomised controlled data proving the benefit of life-style modification in improving mortality and reducing cardiovascular events in patients with PAD. Despite this there is sufficient evidence to recommend some life-style modification as part of the overall approach to risk reduction in these patients. There is compelling evidence to support smoking cessation, increased exercise and improved diet.
回顾已发表的支持在外周动脉疾病（PAD）中采用生活方式改变的证据。
对医学文献进行系统检索以查找相关研究。
然后在获得的出版物中查找报告了各种生活方式改变的死亡率或主要心血管事件发生率等终点指标的随机临床试验。
仅发现一项报告了相关终点指标的随机对照试验。其他试验的终点指标为步行距离或生化标志物等。
缺乏随机对照数据来证明生活方式改变对改善PAD患者死亡率和降低心血管事件的益处。尽管如此，仍有充分证据推荐一些生活方式改变作为这些患者总体风险降低方法的一部分。有令人信服的证据支持戒烟、增加运动和改善饮食。
