Putzhammer Albert, Perfahl Maria, Pfeiff Liane, Broll Karin, Hess Linda, Ibach Bernd
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg.
Psychiatr Prax. 2004 Nov;31 Suppl 1:S164-6. doi: 10.1055/s-2004-828474.
Schizophrenic disorders as well as neuroleptic treatment can affect locomotion. The study assessed the influence of neuroleptic treatment on externally triggered gait on a treadmill at three different velocities via ultrasonic topometric gait analysis. Spatial and temporal gait parameters were assessed in two groups of schizophrenic patients either under treatment with conventional neuroleptics (n = 12) or without neuroleptic treatment (n = 10) and re-assessed after treatment change to the atypical neuroleptic olanzapine in a repeated measures design. After switch from conventional neuroleptics to olanzapine patients showed an increase of step length and decrease of cadence at the low (p </= 0.01) and the intermediately low treadmill velocity (p </= 0.05), whereas the parameters remained stable at the normal gait velocity. Significant differences between the untreated state and treatment with olanzapine were not detectable. We conclude that conventional neuroleptic treatment impairs the regulation of gait parameters and that this effect can be reversed at slow gait velocities by external stimulation via treadmill walking.
精神分裂症以及抗精神病药物治疗都会影响运动能力。该研究通过超声地形步态分析，评估了抗精神病药物治疗对在跑步机上以三种不同速度进行的外部触发步态的影响。在两组精神分裂症患者中评估了空间和时间步态参数，一组接受传统抗精神病药物治疗（n = 12），另一组未接受抗精神病药物治疗（n = 10），并在采用重复测量设计将治疗改为非典型抗精神病药物奥氮平后重新进行评估。从传统抗精神病药物转换为奥氮平后，患者在低跑步机速度（p≤0.01）和中低跑步机速度（p≤0.05）下步长增加，步频降低，而在正常步态速度下参数保持稳定。未检测到未治疗状态与奥氮平治疗之间的显著差异。我们得出结论，传统抗精神病药物治疗会损害步态参数的调节，并且这种影响可以通过在慢步态速度下通过跑步机行走的外部刺激来逆转。
