LeBlanc Casey J, Roberts Christopher S, Bauer Rudy W, Ryan Kirk A
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
Vet Clin Pathol. 2004;33(4):253-6. doi: 10.1111/j.1939-165x.2004.tb00384.x.
A 9-year-old intact male Miniature Schnauzer presented laterally recumbent, cachexic, and dehydrated with multiple firm bone masses and a bilaterally enlarged prostate. Fine-needle aspiration of a rib mass revealed numerous basophilic polygonal to fusiform cells predominantly found in small to large clusters. The cells exhibited cytologic criteria of malignancy and infrequently displayed large cytoplasmic vacuoles containing finely- to coarsely-stippled azurophilic material. The cytologic diagnosis was metastatic adenocarcinoma and was suspected to be prostatic or transitional cell in origin because of the azurophilic vacuoles within malignant cells. Gross and histologic findings confirmed the clinical and cytologic diagnosis of prostatic adenocarcinoma with widespread metastasis. Cytochemical and immunohistochemical investigation confirmed glycogen was a component of the vacuolar material. The vacuoles observed in the tumor in this case are not a consistent finding in tumors of the prostate or urinary bladder; however, when associated with an epithelial tumor, they may aid in limiting the differentials of the primary tumor and in the selection of further diagnostics.
一只9岁未绝育的雄性迷你雪纳瑞犬侧卧就诊，消瘦且脱水，有多个坚硬的骨肿块，前列腺双侧肿大。对肋骨肿块进行细针穿刺，发现大量嗜碱性多边形至梭形细胞，主要呈小至大的簇状分布。这些细胞表现出恶性的细胞学特征，偶尔可见含有细至粗点状嗜天青物质的大细胞质空泡。细胞学诊断为转移性腺癌，由于恶性细胞内有嗜天青空泡，怀疑起源于前列腺或移行细胞。大体和组织学检查结果证实了前列腺腺癌伴广泛转移的临床和细胞学诊断。细胞化学和免疫组织化学研究证实糖原是液泡物质的组成成分。在该病例肿瘤中观察到的空泡在前列腺或膀胱肿瘤中并非一致的表现；然而，当与上皮性肿瘤相关时，它们可能有助于缩小原发性肿瘤的鉴别诊断范围并指导进一步的诊断选择。
