Steiger M J, Pires M, Scaravilli F, Quinn N P, Marsden C D
Department of Clinical Neurology, Institute of Neurology, London, U.K.
Mov Disord. 1992;7(1):71-7. doi: 10.1002/mds.870070115.
Dyskinesias associated with dopaminergic treatment in idiopathic Parkinson's disease (PD) can be indistinguishable from those arising spontaneously in other conditions involving degeneration of, or damage to, the basal ganglia. However, those due to levodopa treatment of PD disappear on cessation of therapy. We report a patient with a clinical diagnosis of PD who, on levodopa treatment, developed hemiballism and chorea that were originally thought to be drug induced. However, the dyskinesias persisted despite stopping levodopa. Postmortem analysis showed a multisystem degeneration.
特发性帕金森病（PD）中与多巴胺能治疗相关的运动障碍，可能与其他涉及基底神经节变性或损伤的疾病中自发出现的运动障碍难以区分。然而，帕金森病左旋多巴治疗所致的运动障碍在停药后会消失。我们报告了一名临床诊断为帕金森病的患者，在接受左旋多巴治疗时出现了偏身投掷症和舞蹈症，最初认为是药物所致。然而，尽管停用了左旋多巴，运动障碍仍持续存在。尸检分析显示有多系统变性。
