Zimmerman T R, Sage J I, Lang A E, Mark M H
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Mov Disord. 1994 Mar;9(2):173-7. doi: 10.1002/mds.870090208.
We report four patients with Parkinson's disease who had an unusual pattern of severe chorea and dystonia in the evenings only. The temporal pattern of abnormal movements and simultaneous monitoring of plasma levodopa and clinical state were consistent with dyskinesias associated with subtherapeutic (low dopa dyskinesias) rather than peak concentrations of levodopa (high dopa dyskinesias). In two patients, addition of a direct-acting dopamine receptor agonist was helpful in ameliorating this complication of antiparkinson therapy.
我们报告了4例帕金森病患者，他们仅在傍晚出现一种不寻常的严重舞蹈症和肌张力障碍模式。异常运动的时间模式以及血浆左旋多巴和临床状态的同步监测结果与低于治疗剂量相关的异动症（低剂量多巴异动症）而非左旋多巴峰值浓度相关的异动症（高剂量多巴异动症）相符。在2例患者中，加用一种直接作用的多巴胺受体激动剂有助于改善抗帕金森治疗的这一并发症。
