Nygaard Harald A, Ruths Sabine, Straand Jørund, Naik Mala
Section for Geriatric Medicine, Department of Public Health and Primary Health Care, University of Bergen, Norway.
Aging Clin Exp Res. 2004 Aug;16(4):277-82. doi: 10.1007/BF03324552.
The use of psychotropic drugs in nursing homes is generally considered to be inappropriately high. The aim of the present survey was to compare psychotropic drug use in nursing homes (NHs) in 1985 relative to 1996/97, and to explore predictors for this drug use.
Cross-sectional study. Mental capacity was assessed by means of the Clinical Dementia Rating scale (CDR), and behavior registered by trained nurses. Scheduled, daily use of psychotropic drugs among long-term care residents in 1985 (N=1247) and 1996/97 (N=1035) was recorded. Bivariate analyses and logistic regression analyses were applied to establish predictors for psychoactive drug use.
From 1985 to 1996/97, the proportion of residents using any psychotropic drug increased from 52 to 57%. Antipsychotic drug use decreased from 33 to 22%, while anxiolytics increased from 11 to 16%, hypnotics from 11 to 14%, and antidepressants from 12 to 31%. Psychotropic drug use was predominantly associated with behavioral symptoms and not with mental impairment. Concurrent use of two or more psychotropic drugs increased from 23 to 32% of all psychotropic users.
During the study period, a substantial decline in the use of antipsychotics was observed, but a generally increased overall use of psychotropic drugs, particularly antidepressants. Psychotropic drug treatment was mainly associated with behavioral symptoms.
疗养院中精神药物的使用普遍被认为过高。本次调查的目的是比较1985年与1996/97年疗养院中精神药物的使用情况,并探究这种药物使用的预测因素。
横断面研究。通过临床痴呆评定量表(CDR)评估精神能力,由经过培训的护士记录行为表现。记录了1985年(N = 1247)和1996/97年(N = 1035)长期护理居民中按计划每日使用精神药物的情况。采用双变量分析和逻辑回归分析来确定精神活性药物使用的预测因素。
从1985年到1996/97年,使用任何精神药物的居民比例从52%上升至57%。抗精神病药物的使用从33%降至22%,而抗焦虑药从11%增至16%,催眠药从11%增至14%,抗抑郁药从12%增至31%。精神药物的使用主要与行为症状相关,而非与精神损害相关。同时使用两种或更多种精神药物的情况在所有精神药物使用者中从23%增至32%。
在研究期间,观察到抗精神病药物的使用大幅下降,但精神药物的总体使用普遍增加,尤其是抗抑郁药。精神药物治疗主要与行为症状相关。