Khamitov R F, Pal'mova L Iu, Novozhenov V G
Ter Arkh. 2004;76(10):91-4.
To study effects of eradication of Chlamydophila pneumoniae CP) infection in bronchial asthma (BA) on BA course and changes in quality of life (QOL) in BA patients.
194 BA patients in clinical remission participated in the trial. Microbiological diagnosis of asymptomatic CP infection was made serologically (ELISA, indirect enzyme immunoassay) using polymerase chain reaction. Clinical and biochemical tests, assessment of pulmonary ventilation function, QOL by AQLQ during 6-week antimicrobial therapy were made in 56 patients.
Patients with stable BA had high frequency of serological signs of clinically asymptomatic CP infection (52%) deteriorating BA symptoms and QOL. Antibacterial therapy of latent CP infection with azitromycin significantly improved BA course and QOL of BA patients.
When laboratory tests detect CP infection in patients with long-term course of BA, especially in smoking males with moderate and severe BA it is clinically valid to prescribe addition of azitromycin to basic antiinflammatory treatment of BA.
研究根除支气管哮喘（BA）患者肺炎衣原体（CP）感染对BA病程及患者生活质量（QOL）变化的影响。
194例处于临床缓解期的BA患者参与了该试验。采用聚合酶链反应，通过血清学方法（ELISA，间接酶免疫测定）对无症状CP感染进行微生物学诊断。对56例患者在为期6周的抗菌治疗期间进行了临床和生化检查、肺通气功能评估以及使用AQLQ进行生活质量评估。
稳定期BA患者中，临床无症状CP感染的血清学指标出现频率较高（52%），这会使BA症状和生活质量恶化。用阿奇霉素对潜伏性CP感染进行抗菌治疗可显著改善BA病程及BA患者的生活质量。
当实验室检查发现长期患BA的患者存在CP感染时，尤其是患有中度和重度BA的吸烟男性患者，在BA的基础抗炎治疗中加用阿奇霉素在临床上是有效的。
