Tumanova-Ponomareva N F, Shmelev E I
Ter Arkh. 2006;78(3):35-9.
To study clinicolaboratory signs of respiratory infection in patients with bronchial asthma (BA).
Respiratory infection and its influence on BA were studied in 108 BA patients (66 female and 42 male, mean age 51.0 +/- 15.2 years) with symptoms of bronchitis and non-nosocomial (n = 71) and nosocomial (n = 37) pneumonia. The patients referred for medical care and started antibacterial therapy (ABT) after 4.7 +/- 2.8 days of respiratory infection (RI). Before assignment to the trial BA exacerbation ran for 9.8 +/- 6.0 days.
RI preceded BA exacerbation in 62% patients with pneumonia. BA exacerbation preceded RI in 66% patients with bronchitis. RI ran with moderate and severe intoxication. Severity of BA exacerbation correlated with severity of RI Antibacterial treatment was uneffective and the drugs were changed for others in 18% bronchitis and 16% pneumonia patients. Laboratory signs of inflammation were more obvious in pneumonias than in bronchitis and did not depend on the disease severity. External respiration function at RI onset was significantly affected in all the patients.
Respiratory infections aggravate the course of BA and damage external respiration function.
研究支气管哮喘（BA）患者呼吸道感染的临床实验室指标。
对108例有支气管炎症状以及非医院获得性肺炎（n = 71）和医院获得性肺炎（n = 37）的BA患者（66例女性和42例男性，平均年龄51.0±15.2岁）的呼吸道感染及其对BA的影响进行了研究。患者在呼吸道感染（RI）4.7±2.8天后就医并开始抗菌治疗（ABT）。在纳入试验前，BA加重持续9.8±6.0天。
62%的肺炎患者RI先于BA加重。66%的支气管炎患者BA加重先于RI。RI伴有中度和重度中毒症状。BA加重的严重程度与RI的严重程度相关。18%的支气管炎患者和16%的肺炎患者抗菌治疗无效，需更换药物。肺炎患者炎症的实验室指标比支气管炎患者更明显，且与疾病严重程度无关。所有患者在RI发作时的外呼吸功能均受到显著影响。
呼吸道感染会加重BA的病程并损害外呼吸功能。
