Wieand S, Cha S
Cancer Center Statistics, Mayo Clinic, Rochester, MN 55905.
Stat Med. 1992 Jan 15;11(1):5-11. doi: 10.1002/sim.4780110103.
A screening design was used in a trial that compared a standard regimen to five experimental regimens for the treatment of advanced colorectal cancer where the endpoint was survival. The two-stage design permitted the termination of accrual to experimental regimens that failed to show promise at the first stage. It also allowed for termination of accrual to the standard regimen if an experimental regimen appeared to offer a highly significant improvement over the standard regimen. This paper presents a description of the design and the results of the trial.
在一项试验中采用了一种筛选设计，该试验将一种标准治疗方案与五种治疗晚期结直肠癌的试验方案进行比较，终点指标为生存率。两阶段设计允许在第一阶段未显示出前景的试验方案停止入组。如果一种试验方案似乎比标准方案有非常显著的改善，也允许停止标准方案的入组。本文介绍了该设计及试验结果。
