Takahashi Kazuhiro, Kawagoe Jun, Ohmichi Masahide, Kurachi Hirohisa
Department of Obstetrics and Gynecology, Yamagata University School of Medicine.
Clin Calcium. 2004 Mar;14(3):436-41.
Estrogen deficiency is one significant cause of accelerated bone loss in women during and after menopause. Postmenopausal osteoporosis is a major health problem, primarily because of the severe morbidity and mortality associated with osteoporotic fractures. The Women's Health Initiative Study (WHI) reported that hormone replacement therapy (HRT) prevented osteoporotic fractures. The risks and benefits of HRT are complex and require the individual assessment of each woman considering taking HRT. Use of HRT can be considered as a treatment option for osteoporosis but the risks and benefits should be discussed with each individual woman before starting treatment.
雌激素缺乏是女性绝经期间及绝经后骨质流失加速的一个重要原因。绝经后骨质疏松症是一个主要的健康问题，主要是因为与骨质疏松性骨折相关的严重发病率和死亡率。妇女健康倡议研究（WHI）报告称，激素替代疗法（HRT）可预防骨质疏松性骨折。HRT的风险和益处很复杂，需要对考虑接受HRT的每位女性进行个体评估。HRT的使用可被视为骨质疏松症的一种治疗选择，但在开始治疗前应与每位女性讨论其风险和益处。
