Tarakida Ayako, Higuchi Tsuyoshi, Mizunuma Hideki
Hirosaki University, School of Medicine, Department of Obstetrics and Gynecology.
Clin Calcium. 2008 Oct;18(10):1434-41.
Postmenopausal bone estrogen deficiency causes rapid bone loss. Therefore hormone replacement therapy (HRT) has been considered as a rational therapy for postmenopausal not only for osteopenia but also osteoporosis. The results of Women's Health Initiative (WHI) hormone trial had given the strong restriction on HRT. However recent closer analyses have shown that HRT initiated for early menopausal women brings many benefits without elevation of the risks, and that the appropriate selection of dose level or a way to apply can also reduce the risks of HRT. HRT has many physiological effects that were not seen in other drugs and so HRT can be considered as one of the most effective treatment for postmenopausal osteoporosis.
绝经后骨雌激素缺乏会导致快速的骨质流失。因此，激素替代疗法（HRT）不仅被视为绝经后骨质减少和骨质疏松的合理治疗方法。妇女健康倡议（WHI）激素试验的结果对HRT施加了严格限制。然而，最近更深入的分析表明，对早期绝经女性开始使用HRT会带来许多益处且不会增加风险，并且适当选择剂量水平或应用方式也可以降低HRT的风险。HRT具有许多其他药物所没有的生理效应，因此HRT可被视为绝经后骨质疏松症最有效的治疗方法之一。
