Hara Shino, Yokoyama Keitaro
Division of kidney and hypertension, Department of Internal Medicine, Jikei University School of Medicine.
Clin Calcium. 2004 May;14(5):752-5.
Vascular calcification is clinically important, because it predicts a higher risk of cardiovascular event. Its pathogenesis involve atherosclerosis and regulated by mechanism which like bone metabolism. In dialysis patients, there is excess oxidative stress, shortage of scavenger, metabolic abnormality of calcium and phosphate. These factors may accelerate vascular calcification in dialysis patient. K/DOQI guideline shows the therapeutic strategy for calcium and phosphate metabolic abnormality. It is expected more progression in therapy for vascular calcification.
血管钙化在临床上具有重要意义,因为它预示着心血管事件的高风险。其发病机制涉及动脉粥样硬化,并受类似骨代谢的机制调节。在透析患者中,存在氧化应激过剩、清除剂缺乏以及钙和磷的代谢异常。这些因素可能加速透析患者的血管钙化。K/DOQI指南显示了针对钙和磷代谢异常的治疗策略。预计血管钙化治疗会有更大进展。