[SERM and quality of bone].

Now, we can prevent osteoporotic fractures by improvement of bone strength. It became clear that not only the increase of bone mineral density but also the improvement of bone quality are important factors for the mechanisms of preventing fractures. Measuring bone metabolism markers is contributing to evaluate bone quality. We presume SERM demonstrates a sustained fracture preventive effect through 4 yrs by normalizing the bone metabolism of postmenopausal women with osteoporosis.