Slattery Martha L, Murtaugh Maureen, Caan Bette, Ma Khe Ni, Wolff Roger, Samowitz Wade
Health Research Center, University of Utah, Salt Lake City, Utah 84108, USA.
Cancer Causes Control. 2004 Nov;15(9):863-72. doi: 10.1007/s10552-004-1048-6.
Components of energy balance are important elements associated with colorectal cancer risk. In this study we examine the association between VDR genotypes, BMI, physical activity, and energy intake and risk of colorectal cancer. Data from a population-based case-control study of colon (1174 cases and 1174 controls) and rectal (785 cases and 1000 controls) cancer was used to evaluate the associations. The Bsm1, polyA, and Fok1 VDR polymorphisms were evaluated. For colon cancer, those who are obese were at greater risk of colon cancer if they had the SS or BB (OR = 3.50; 95% CI = 1.75-7.03; p interaction 0.03) or ff (OR = 2.62; 95% CI = 1.15-5.99; p interaction 0.12/) VDR genotypes. On the other hand, those who were least physically active were at greater risk of colon cancer if they had the ff VDR genotype (OR = 3.46; 95% CI = 1.58-7.58; p interaction 0.05). The association between energy intake and colon cancer appears to be driven more by energy intake than Bsm1 or polyA VDR genotypes, although there was a significant interaction between the Fok1 VDR polymorphism and energy intake and risk of both colon and rectal cancer (p interaction 0.01 for colon and 0.04 for rectal). These data suggest a relationship between VDR genotype and factors related to energy balance in modifying colorectal cancer risk.
能量平衡的组成部分是与结直肠癌风险相关的重要因素。在本研究中，我们考察了维生素D受体（VDR）基因型、体重指数（BMI）、身体活动和能量摄入与结直肠癌风险之间的关联。来自一项基于人群的结肠癌（1174例病例和1174例对照）和直肠癌（785例病例和1000例对照）病例对照研究的数据用于评估这些关联。对Bsm1、polyA和Fok1 VDR基因多态性进行了评估。对于结肠癌，肥胖者若具有SS或BB（比值比[OR]=3.50；95%置信区间[CI]=1.75 - 7.03；交互作用p值=0.03）或ff（OR = 2.62；95% CI = 1.15 - 5.99；交互作用p值=0.12）VDR基因型，则患结肠癌的风险更高。另一方面，身体活动最少的人若具有ff VDR基因型，则患结肠癌的风险更高（OR = 3.46；95% CI = 1.58 - 7.58；交互作用p值=0.05）。能量摄入与结肠癌之间的关联似乎更多地由能量摄入驱动，而非Bsm1或polyA VDR基因型，尽管Fok1 VDR基因多态性与能量摄入以及结肠癌和直肠癌风险之间存在显著交互作用（结肠癌交互作用p值=0.01，直肠癌交互作用p值=0.04）。这些数据表明VDR基因型与能量平衡相关因素在改变结直肠癌风险方面存在关联。
