Min Sherene S, Corbett Amanda H, Rezk Naser, Cu-Uvin Susan, Fiscus Susan A, Petch Leslie, Cohen Myron S, Kashuba Angela D M
Schools of Medicine, University of North Carolina, Chapel Hill 27599-7360, USA.
J Acquir Immune Defic Syndr. 2004 Dec 15;37(5):1577-80. doi: 10.1097/00126334-200412150-00008.
The pharmacokinetics of antiretrovirals (ARVs) in the female genital tract (FGT) are likely to influence vertical and sexual transmission of HIV, the development of viral resistance, and post-exposure prophylaxis regimens. This study is the first to compare ARV concentrations in direct aspirates of cervicovaginal fluid (CVF) and blood plasma (BP). This unique method provides direct assessment of concentrations without the confounding of cervicovaginal lavage dilution. Of 8 ARVs, CVF concentrations ranged from <10% to >100% of BP concentrations. These large differences in CVF penetration suggest that further research into ARV pharmacokinetics and drug efficacy in the FGT is necessary.
抗逆转录病毒药物（ARV）在女性生殖道（FGT）中的药代动力学可能会影响HIV的垂直传播和性传播、病毒耐药性的发展以及暴露后预防方案。本研究首次比较了宫颈阴道液（CVF）直接抽吸物和血浆（BP）中ARV的浓度。这种独特的方法可直接评估浓度，而不会受到宫颈阴道灌洗稀释的干扰。在8种ARV中，CVF浓度范围为BP浓度的<10%至>100%。CVF渗透的这些巨大差异表明，有必要进一步研究FGT中ARV的药代动力学和药物疗效。
