含拉替拉韦方案治疗的 HIV-1 感染女性生殖道内拉替拉韦浓度（DIVA 01 研究）。
Raltegravir concentrations in the genital tract of HIV-1-infected women treated with a raltegravir-containing regimen (DIVA 01 study).
机构信息
Department of Infectious Diseases, Pitié-Salpêtrière Hospital, Boulevard de l'Hôpital, Paris 75013, France.
出版信息
Antimicrob Agents Chemother. 2011 Jun;55(6):3018-21. doi: 10.1128/AAC.01460-10. Epub 2011 Mar 28.
Abstract
We studied the penetration of raltegravir and HIV shedding in the genital tract among 14 HIV-1-infected women receiving a raltegravir-containing regimen who had <40 copies/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median raltegravir concentrations were 235 ng/ml in BP and 93 ng/ml in CVF, with a CVF/BP ratio of approximately 2.3. This good penetration of raltegravir may contribute to the control of viral replication in the female genital tract.
摘要
我们研究了 14 名接受含拉替拉韦方案治疗且血液血浆（BP）HIV RNA<40 拷贝/ml 的 HIV-1 感染女性的生殖道中拉替拉韦的渗透和 HIV 脱落情况。没有宫颈阴道分泌物（CVF）样本显示可检测到的 HIV RNA。BP 中的中位数拉替拉韦浓度为 235ng/ml，CVF 中的中位数为 93ng/ml，CVF/BP 比值约为 2.3。拉替拉韦的这种良好渗透可能有助于控制女性生殖道中的病毒复制。
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