Parvizi Javad, Wickstrom Eric, Zeiger Allen R, Adams Christopher S, Shapiro Irving M, Purtill James J, Sharkey Peter F, Hozack William J, Rothman Richard H, Hickok Noreen J
Department of Orthopaedic Surgery, WORK, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Clin Orthop Relat Res. 2004 Dec(429):33-8. doi: 10.1097/01.blo.0000150116.65231.45.
Despite immense improvements, periprosthetic infection continues to compromise the result of otherwise successful joint arthroplasty. There are various limitations in the treatment of periprosthetic infection, the most important of which is the inability to deliver antibiotics to the local tissue without the need for intravenous administration. We have developed a novel route to covalently tether vancomycin to a metal (titanium) surface, which showed effective bactericidal activity because of a vancomycin coupling. The chemistry of tethering does not affect the biological activity of the biofactors that are attached to the metal surface. This technology holds great promise for the manufacturing of "smart" implants that can be self protective against periprosthetic infection, or can be used for the treatment of periprosthetic infections when they occur.
尽管取得了巨大进展，但假体周围感染仍然会影响原本成功的关节置换手术的效果。假体周围感染的治疗存在各种局限性，其中最重要的是无法在无需静脉给药的情况下将抗生素输送到局部组织。我们开发了一种将万古霉素共价连接到金属（钛）表面的新方法，由于万古霉素偶联，该方法显示出有效的杀菌活性。连接的化学过程不会影响附着在金属表面的生物因子的生物活性。这项技术在制造能够自我预防假体周围感染的“智能”植入物方面具有巨大潜力，或者在假体周围感染发生时可用于治疗。
