Department of Orthopaedic Surgery, UC Davis Medical Center, Sacramento, California.
Semin Plast Surg. 2009 May;23(2):100-7. doi: 10.1055/s-0029-1214162.
The local delivery of antibiotics in the treatment of osteomyelitis has been used safely and effectively for decades. Multiple methods of drug delivery have been developed for the purposes of both infection treatment and prophylaxis. The mainstay of treatment in this application over the past 20 years has been non-biodegradable polymethylmethacrylate, which has the advantages of excellent elution characteristics and structural support properties. Biodegradable materials such as calcium sulfate and bone graft substitutes have been used more recently for this purpose. Other biodegradable implants, including synthetic polymers, are not yet approved for use but have demonstrated potential in laboratory investigations. Antibiotic-impregnated metal, a recent development, holds great promise in the treatment and prophylaxis of osteomyelitis in the years to come.
局部递送抗生素治疗骨髓炎已安全有效地应用了数十年。为了治疗和预防感染，已经开发出多种药物递送方法。在过去 20 年中，这种应用的主要治疗方法是不可生物降解的聚甲基丙烯酸甲酯，它具有出色的洗脱特性和结构支撑性能。最近，硫酸钙和骨移植替代物等可生物降解材料也被用于此目的。其他可生物降解的植入物，包括合成聚合物，尚未被批准用于临床，但在实验室研究中显示出了潜力。最近开发的抗生素浸渍金属在未来治疗和预防骨髓炎方面具有很大的应用前景。
