Valer Luisa, Martín-Carbonero Luz, de Mendoza Carmen, Corral Angélica, Soriano Vincent
Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
AIDS. 2004 Oct 21;18(15):2094-6. doi: 10.1097/00002030-200410210-00018.
Over the past 5 years, 1846 HIV-infected patients underwent drug resistance testing at our institution. None out of 216 drug-naive subjects showed K65R. However, it was recognized in 53 out of 1630 antiretroviral-experienced patients (3.3%), of whom 10 had never been exposed to tenofovir. The rate of K65R increased from 0.6% in 1999 to 11.5% in 2004. The recognition of K65R correlated negatively with the presence of thymidine analogue mutations but positively with Q151M.
在过去5年中，1846例HIV感染患者在我们机构接受了耐药性检测。216例初治患者中无一例出现K65R。然而，在1630例有抗逆转录病毒治疗经验的患者中有53例（3.3%）出现了K65R，其中10例从未接触过替诺福韦。K65R的发生率从1999年的0.6%上升至2004年的11.5%。K65R的出现与胸苷类似物突变呈负相关，但与Q151M呈正相关。
