Kawaguchi Mio, Adachi Mitsuru, Oda Naruhito, Kokubu Fumio, Huang Shau-Ku
Johns Hopkins University, Asthma and Allergy Center, Baltimore, MD 21224, USA.
J Allergy Clin Immunol. 2004 Dec;114(6):1265-73; quiz 1274. doi: 10.1016/j.jaci.2004.10.019.
A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo , and have been shown to be proinflammatory in nature. This proinflammatory activity is exemplified by their involvement in pulmonary inflammatory responses, in which both IL-17A and IL-17F are involved in the recruitment of neutrophils, and IL-17E is able to induce T H 2 cytokine production and eosinophilia. Although the elucidation of a detailed mechanism of action continues to be an active area of research, the potent inflammatory activity and its association with various human disease states suggest this new cytokine family as an important contributor to the pathophysiology of human disease conditions, in particular the pulmonary diseases.
最近定义了一个新的细胞因子家族——白细胞介素-17（IL-17），它揭示了一种独特的配体-受体信号系统。功能研究已为其在免疫反应调节中的重要性提供了证据。值得注意的是，白细胞介素-17A、白细胞介素-17E（IL-25）和白细胞介素-17F这三个成员在体外和体内都得到了最充分的表征，并且已被证明本质上具有促炎作用。它们参与肺部炎症反应就例证了这种促炎活性，其中白细胞介素-17A和白细胞介素-17F都参与中性粒细胞的募集，而白细胞介素-17E能够诱导辅助性T细胞2（TH2）细胞因子的产生和嗜酸性粒细胞增多。尽管对详细作用机制的阐明仍是一个活跃的研究领域，但这种强大的炎症活性及其与各种人类疾病状态的关联表明，这个新的细胞因子家族是人类疾病病理生理学的重要促成因素，尤其是肺部疾病。
