College of Pharmacy, Zunyi Medical University, Zunyi, 563006, China.
Key Lab of the Basic Pharmacology of the Ministry of Education & Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563006, China.
Cell Commun Signal. 2024 May 27;22(1):288. doi: 10.1186/s12964-024-01668-w.
Chronic wounds, resulting from persistent inflammation, can trigger a cascade of detrimental effects including exacerbating inflammatory cytokines, compromised blood circulation at the wound site, elevation of white blood cell count, increased reactive oxygen species, and the potential risk of bacterial infection. The interleukin-17 (IL-17) signaling pathway, which plays a crucial role in regulating immune responses, has been identified as a promising target for treating inflammatory skin diseases. This review aims to delve deeper into the potential pathological role and molecular mechanisms of the IL-17 family and its pathways in wound repair. The intricate interactions between IL-17 and other cytokines will be discussed in detail, along with the activation of various signaling pathways, to provide a comprehensive understanding of IL-17's involvement in chronic wound inflammation and repair.
慢性创面是由持续的炎症引起的，会引发一连串有害的影响，包括炎症细胞因子的恶化、创面处血液循环受损、白细胞计数增加、活性氧增加，以及细菌感染的潜在风险。白细胞介素-17（IL-17）信号通路在调节免疫反应中起着关键作用，已被确定为治疗炎症性皮肤病的有前途的靶点。本综述旨在深入探讨 IL-17 家族及其通路在创面修复中的潜在病理作用和分子机制。IL-17 与其他细胞因子之间的复杂相互作用，以及各种信号通路的激活，将被详细讨论，以全面了解 IL-17 参与慢性创面炎症和修复的过程。
