Lederman Sally Ann, Rauh Virginia, Weiss Lisa, Stein Janet L, Hoepner Lori A, Becker Mark, Perera Frederica P
Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA.
Environ Health Perspect. 2004 Dec;112(17):1772-8. doi: 10.1289/ehp.7348.
The effects of prenatal exposure to pollutants from the World Trade Center (WTC) disaster on fetal growth and subsequent health and development of exposed children remain a source of concern. We assessed the impact of gestational timing of the disaster and distance from the WTC in the 4 weeks after 11 September on the birth outcomes of 300 nonsmoking women who were pregnant at the time of the event. They were recruited at delivery between December 2001 and June 2002 from three hospitals close to the WTC site. Residential and work addresses of all participants for each of the 4 weeks after 11 September 2001 were geocoded for classification by place and timing of exposure. Average daily hours spent at each location were based on the women's reports for each week. Biomedical pregnancy and delivery data extracted from the medical records of each mother and newborn included medical complications, type of delivery, length of gestation, birth weight, birth length, and head circumference. Term infants born to women who were pregnant on 11 September 2001 and who were living within a 2-mile radius of the WTC during the month after the event showed significant decrements in term birth weight (-149 g) and birth length (-0.82 cm), compared with infants born to the other pregnant women studied, after controlling for sociodemographic and biomedical risk factors. The decrements remained significant with adjustment for gestational duration (-122 g and -0.74 cm, respectively). Women in the first trimester of pregnancy at the time of the WTC event delivered infants with significantly shorter gestation (-3.6 days) and a smaller head circumference (-0.48 cm), compared with women at later stages of pregnancy, regardless of the distance of their residence or work sites from the WTC. The observed adverse effects suggest an impact of pollutants and/or stress related to the WTC disaster and have implications for the health and development of exposed children.
产前接触世界贸易中心（WTC）灾难产生的污染物对胎儿生长以及受影响儿童随后的健康和发育的影响，仍然令人担忧。我们评估了灾难发生时的孕周以及9月11日后4周内距世贸中心的距离，对事件发生时怀孕的300名不吸烟女性分娩结局的影响。她们于2001年12月至2002年6月在靠近世贸中心遗址的三家医院分娩时被招募。对2001年9月11日后4周内所有参与者的居住和工作地址进行地理编码，以便按接触地点和时间进行分类。每个地点的平均每日停留时间基于女性每周的报告。从每位母亲和新生儿的医疗记录中提取的生物医学妊娠和分娩数据包括医疗并发症、分娩类型、孕周、出生体重、出生身长和头围。在控制了社会人口统计学和生物医学风险因素后，2001年9月11日怀孕且事件发生后一个月内居住在世贸中心半径2英里范围内的女性所生足月儿，与其他研究的孕妇所生婴儿相比，足月儿出生体重显著下降（-149克），出生身长显著下降（-0.82厘米）。调整孕周后，下降幅度仍然显著（分别为-122克和-0.74厘米）。世贸中心事件发生时处于妊娠早期的女性所生婴儿的孕周明显较短（-3.6天），头围较小（-0.48厘米），与妊娠后期的女性相比，无论其居住或工作地点距世贸中心的距离如何。观察到的不良影响表明，与世贸中心灾难相关的污染物和/或压力产生了影响，并对受影响儿童的健康和发育具有启示意义。
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