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原发性腹膜炎合并链球菌中毒性休克样综合征:1例报告

Primary peritonitis associated with streptococcal toxic shock-like syndrome: report of a case.

作者信息

Kanetake Kazuto, Hayashi Masatomo, Hino Akitsugu, Futamura Naoki, Mori Yoshio, Takagi Hisato, Iwata Hisashi, Sakamoto Ken-ichi, Kumada Yoshitaka, Matsuo Hiroshi, Hirose Hajime

机构信息

First Department of Surgery, Gifu University School of Medicine, 40 Tsukasamachi, Gifu 500-8705, Japan.

出版信息

Surg Today. 2004;34(12):1053-6. doi: 10.1007/s00595-004-2863-9.

Abstract

Several reports over the past 15 years describe severe group A streptococcal infections causing septic shock, soft-tissue necrosis, and multiple organ failure; a phenomenon known as streptococcal toxic shock-like syndrome (TSLS). However, primary peritonitis associated with TSLS is rare. We report the case of a 40-year-old man admitted with pain in both thighs, hypotension, and severe abdominal pain. His daughter had been diagnosed with streptococcal pharyngitis 3 days earlier. We performed an emergency laparotomy for peritonitis, and culture of the ascites was positive for group A beta -hemolytic streptococcus (GAS). Further serotyping of the isolated GAS strain revealed the T-type 22 and the pyrogenic exotoxin gene, spe-C. The criteria for TSLS were clearly met, including the isolation of GAS from ascites, hypotension, liver failure, renal failure, coagulopathy, myositis, and a generalized erythematous macular rash with desquamation.

摘要

过去15年中有多篇报道描述了A组链球菌严重感染可导致感染性休克、软组织坏死和多器官功能衰竭;这一现象被称为链球菌中毒性休克样综合征(TSLS)。然而,与TSLS相关的原发性腹膜炎较为罕见。我们报告了一例40岁男性患者,因双大腿疼痛、低血压和严重腹痛入院。他的女儿在3天前被诊断为链球菌性咽炎。我们对腹膜炎患者进行了急诊剖腹手术,腹水培养显示A组β溶血性链球菌(GAS)呈阳性。对分离出的GAS菌株进一步进行血清分型,结果显示为T-22型以及致热外毒素基因spe-C。该病例明确符合TSLS的诊断标准,包括腹水分离出GAS、低血压、肝功能衰竭、肾功能衰竭、凝血病、肌炎以及伴有脱屑的全身性红斑疹。

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