使用光学相干断层扫描技术测量正常犬和患有视网膜色素变性1型（RCD1）犬的视网膜厚度。

Retinal thickness in normal and RCD1 dogs using optical coherence tomography.

作者信息

Panzan Carla Q, Güven Dilek, Weiland James D, Lakhanpal Rohit R, Javaheri Michael, de Juan Eugene, Humayun Mark S

机构信息

Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

出版信息

Ophthalmic Surg Lasers Imaging. 2004 Nov-Dec;35(6):485-93.

PMID:15580972

Abstract

BACKGROUND AND OBJECTIVE

To compare retinal thickness and retinal nerve fiber layer (RNFL) thickness values obtained by optical coherence tomography (OCT) in normal dogs and dogs with rod-cone dysplasia type 1 (RCD1).

MATERIALS AND METHODS

Eight eyes of 6 normal hound-bred dogs and 12 eyes of 6 dogs with RCD1, 2 to 5 years of age, were examined using the Fast RNFL Thickness, Fast Macular Thickness, and line scan protocols of OCT.

RESULTS

Retinal thickness was significantly higher in the tapetal fundus than in the non-tapetal fundus, in both normal (P = .0036) and RCD1 (P < .0001) dogs. Superotemporal, superonasal, and inferior retinal thickness values were significantly higher in normal dogs (P < .0001). Area centralis thickness was 183.5 +/- 10.66 microm in normal dogs and 136.16 +/- 13.12 microm in RCD1 dogs (P < .0001). There was no difference in RNFL thickness between normal and RCD1 dogs (P > .05).

CONCLUSION

OCT scanning in dogs is considered to be a useful method of evaluation in future retinal studies in this animal model.

摘要

背景与目的

比较正常犬和患有1型视锥视杆细胞营养不良（RCD1）的犬通过光学相干断层扫描（OCT）获得的视网膜厚度和视网膜神经纤维层（RNFL）厚度值。

材料与方法

使用OCT的快速RNFL厚度、快速黄斑厚度和线扫描方案，对6只正常猎犬品种犬的8只眼以及6只2至5岁患有RCD1的犬的12只眼进行了检查。

结果

在正常犬（P = .0036）和患有RCD1的犬（P < .0001）中，反光眼底的视网膜厚度均显著高于非反光眼底。正常犬的颞上、鼻上和下方视网膜厚度值显著更高（P < .0001）。正常犬的中央凹厚度为183.5±10.66微米，患有RCD1的犬为136.16±13.12微米（P < .0001）。正常犬和患有RCD1的犬之间的RNFL厚度没有差异（P > .05）。