原发性阴道淋巴瘤中的爱泼斯坦-巴尔病毒阳性
Epstein-Barr virus positivity in primary vaginal lymphoma.
作者信息
Domingo S, Perales A, Torres V, Alcaraz M J, Pellicer A
机构信息
Department of Obstetrics and Gynaecology, Hospital Universitario Dr. Peset, Avda. Gaspar Aguilar 90, Valencia 46017, Spain.
出版信息
Gynecol Oncol. 2004 Dec;95(3):719-21. doi: 10.1016/j.ygyno.2004.08.048.
BACKGROUND
Primary non-Hodgkin lymphoma (NHL) of the vagina is a rare location. Its association with the Epstein-Barr virus (EBV) has been only reported in another case. We present a new case, emphasizing the oncogenetic relevance of EBV.
CASE REPORT
A 45-year-old woman with a pelvic pain revealed in her vaginal inspection a thick and hard vaginal plug with a "paving stone" appearance. The biopsy reported a vaginal non-Hodgkin lymphoma type B of intermediate cell, with positive result for EBV. After treatment, a complete remission was obtained.
CONCLUSION
The EBV is the main responsible for the non-Hodgkin lymphoma; classified as a group I carcinogen, it has been associated with a variety of neoplastic tumors, although it is unusual with extranodal type B diffuse lymphoma.
背景
原发性阴道非霍奇金淋巴瘤（NHL）是一种罕见的发病部位。其与爱泼斯坦-巴尔病毒（EBV）的关联仅在另一病例中有报道。我们报告一例新病例，强调EBV在肿瘤发生中的相关性。
病例报告
一名45岁女性因盆腔疼痛就诊，阴道检查发现一个质地坚硬、呈“铺路石”样外观的厚实阴道肿物。活检报告为中间细胞型B类阴道非霍奇金淋巴瘤，EBV检测呈阳性。经过治疗，实现了完全缓解。
结论
EBV是导致非霍奇金淋巴瘤的主要原因；它被归类为I类致癌物，与多种肿瘤相关，尽管在结外B型弥漫性淋巴瘤中并不常见。
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