Delaire Stephanie, Huang Yina Hsing, Chan Shaio Wei, Robey Ellen A
Department of Molecular and Cell Biology, 475 Life Science Additions, University of California, Berkeley, Berkeley, CA 94720, USA.
J Exp Med. 2004 Dec 6;200(11):1427-35. doi: 10.1084/jem.20041041.
Although stable repression of CD4 and CD8 genes is a central feature of T cell lineage commitment, we lack detailed information about the timing and mechanism of this repression. Stable gene repression has been linked to the position of genes within the nucleus. Therefore, information about the nuclear position of CD4 and CD8 genes during T cell development could provide insights into both the mechanism of regulation of CD4 and CD8 genes, and the process of lineage commitment. Here, we report that lineage-specific repression of CD4 and CD8 genes is associated with the repositioning of alleles close to heterochromatin. We also provide evidence that the relocalization of CD4 and CD8 genes to heterochromatin can occur as an early response to positive selection signals. We discuss our results in terms of our current knowledge of CD4 and CD8 gene regulation and CD4 versus CD8 lineage commitment.
尽管CD4和CD8基因的稳定抑制是T细胞谱系定向的核心特征，但我们缺乏关于这种抑制的时间和机制的详细信息。稳定的基因抑制与基因在细胞核内的位置有关。因此，关于T细胞发育过程中CD4和CD8基因的核位置信息，可能为CD4和CD8基因的调控机制以及谱系定向过程提供见解。在此，我们报告CD4和CD8基因的谱系特异性抑制与等位基因靠近异染色质的重新定位有关。我们还提供证据表明，CD4和CD8基因重新定位到异染色质可作为对阳性选择信号的早期反应而发生。我们根据目前对CD4和CD8基因调控以及CD4与CD8谱系定向的了解来讨论我们的结果。
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