Laboratory of Immune Cell Biology, Center for Cancer Research (CCR), NCI, NIH, Bethesda, MD 20892-4259, USA.
Semin Immunol. 2011 Oct;23(5):360-7. doi: 10.1016/j.smim.2011.08.008. Epub 2011 Oct 1.
The divergence of the two αβ T cell subsets defined by the mutually exclusive expression of CD4 and CD8 glycoproteins is an important event during the intrathymic differentiation of T lymphocytes. This reviews briefly summarizes the mechanisms that promote commitment to the CD4 or CD8 lineage in the thymus, and discusses the transcription factor circuits and epigenetic mechanisms that concur to maintain lineage integrity in post-thymic cells and yet allow effector cell differentiation.
两个αβ T 细胞亚群的分化是 T 淋巴细胞在胸腺内分化过程中的一个重要事件，这两个亚群是通过 CD4 和 CD8 糖蛋白的相互排斥表达来定义的。本文简要总结了促进胸腺中 CD4 或 CD8 谱系定向的机制，并讨论了在胸腺后细胞中维持谱系完整性但又允许效应细胞分化的转录因子回路和表观遗传机制。
