柔毛紫菀中的五环三萜类化合物。

Pentacyclic triterpenoids from Aster ageratoides var. pilosus.

作者信息

Yan Fu-Lin, Wang Ai-Xia, Jia Zhong-Jian

机构信息

College of Chemistry and Chemical Engineering, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.

出版信息

Pharmazie. 2004 Nov;59(11):882-4.

PMID:15587593

Abstract

Two new pentacyclic triterpenoids, 2beta,3beta,16alpha-trihydroxyl-24alpha-al-olean-12-en-28-oic acid (1), 2beta,3beta-dihydroxyl-16-O-beta-D-glucopyranose-24alpha-al-olean-12-en-28-oic acid (2) and two known pentacyclic triterpenoids were isolated from the roots of Aster ageratoides var. pilosus. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2D NMR). In addition, the anti-bacterial activity and anti-tumor activity of compound 2 were tested.

摘要

从少花紫菀的根中分离出两个新的五环三萜类化合物，2β,3β,16α-三羟基-24α-乙酰基齐墩果-12-烯-28-酸（1）、2β,3β-二羟基-16-O-β-D-吡喃葡萄糖基-24α-乙酰基齐墩果-12-烯-28-酸（2）以及两个已知的五环三萜类化合物。通过光谱方法（红外光谱、质谱、一维氢谱、一维碳谱和二维核磁共振谱）对它们的结构进行了鉴定。此外，还测试了化合物2的抗菌活性和抗肿瘤活性。