Wang C X, Shuaib A
Stroke Research Laboratory, University of Alberta, Edmonton, Canada.
Int J Clin Pract. 2004 Oct;58(10):964-9. doi: 10.1111/j.1368-5031.2004.00245.x.
Free radicals play an important role in secondary processes in ischaemic brain injury. Disodium 4-[(tert-butylimino) methyl] benzene-1,3-disulphonate N-oxide (NXY-059) is a nitrone-based free radical trapping agent. Findings from animal stroke models showed that NXY-059 is a potent neuroprotective agent that has a large window of therapeutic opportunity and long-lasting effects. Therefore, NXY-059 may be used as a monotherapy agent for treatment of acute stroke. NXY-059 may also be used as an adjunct agent to thrombolytic therapy, as it can reduce tissue plasminogen activator-induced haemorrhage in ischaemic stroke.
自由基在缺血性脑损伤的继发性过程中起重要作用。4-[(叔丁基亚氨基)甲基]苯-1,3-二磺酸钠N-氧化物（NXY-059）是一种基于硝酮的自由基捕获剂。动物中风模型的研究结果表明，NXY-059是一种有效的神经保护剂，具有较大的治疗机会窗口和持久的效果。因此，NXY-059可作为治疗急性中风的单一治疗剂。NXY-059也可作为溶栓治疗的辅助剂，因为它可以减少缺血性中风中组织纤溶酶原激活剂诱导的出血。
