苏拉明（一种高度带电的多磺酸化萘脲）与来自矛头蝮蛇毒液的肌毒性磷脂酶A2形成的复合物的结晶及初步X射线衍射分析。
Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom.
作者信息
Murakami Mário T, Gava Lisandra M, Zela Sandro P, Arruda Emerson Z, Melo Paulo A, Gutierrez José M, Arni Raghuvir K
机构信息
Departamento de Física, IBILCE, Universidade Estadual Paulista, Cristóvão Colombo, 2265, Nazareth, 15054-000, São José do Rio Preto, SP, Brazil.
出版信息
Biochim Biophys Acta. 2004 Dec 1;1703(1):83-5. doi: 10.1016/j.bbapap.2004.08.009.
Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degrees C. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 angstroms. Diffraction data was collected to 1.78 angstroms.
苏拉明是一种带电量高的多磺酸化萘脲，它会干扰许多生理相关过程，如肌毒性、血液凝固以及多种癌症。这种合成化合物与来自矛头蝮蛇毒液的具有肌毒性的Lys49 PLA(2)复合，并通过悬滴气相扩散法在18摄氏度下结晶。晶体属于正交晶系空间群P2(1)2(1)2(1)，晶胞参数a = 49.05、b = 63.84和c = 85.67埃。衍射数据收集至1.78埃。
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