从皮氏矛头蝮蛇毒中分离得到的肌毒性赖氨酸49 - 磷脂酶A2同系物——皮拉毒素I的结晶。
Crystallization of piratoxin I, a myotoxic Lys49-phospholipase A2 homologue isolated from the venom of Bothrops pirajai.
作者信息
Canduri F, Mancuso L C, Soares A M, Giglio J R, Ward R J, Arni R K
机构信息
Departamento de Física, IBILCE/UNESP, São José do Rio Preto, SP, Brazil.
出版信息
Toxicon. 1998 Mar;36(3):547-51. doi: 10.1016/s0041-0101(97)00120-7.
PMID:9637374
Abstract
Large single crystals of piratoxin I. a Lys49-PLA2 homologue with low enzymatic activity, have been obtained. The crystals belong to the orthorhombic system space group P2(1)2(1)2(1), and diffract X-rays to a resolution of 2.8 A. Preliminary analysis reveals the presence of two molecules in the crystallographic asymmetric unit.
摘要
已获得具有低酶活性的赖氨酸49型磷脂酶A2同系物——海盗毒素I的大单晶。这些晶体属于正交晶系空间群P2(1)2(1)2(1)，并能将X射线衍射到2.8埃的分辨率。初步分析表明，晶体学不对称单元中存在两个分子。
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