Vogt-小柳-原田病患者脑脊液和血清中的趋化因子谱

Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease.

作者信息

Miyazawa Isabelle, Abe Toshiaki, Narikawa Koichi, Feng Juan, Misu Tatsuro, Nakashima Ichiro, Fujimori Juichi, Tamai Makoto, Fujihara Kazuo, Itoyama Yasuto

机构信息

Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan.

出版信息

J Neuroimmunol. 2005 Jan;158(1-2):240-4. doi: 10.1016/j.jneuroim.2004.07.014.

DOI:10.1016/j.jneuroim.2004.07.014

PMID:15589059

Abstract

We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition.

摘要

我们采用酶联免疫吸附测定法（ELISA）分析了伏格特-小柳-原田病（VKH）患者脑脊液（CSF）和血清中四种趋化因子的浓度。VKH是一种针对黑素细胞相关蛋白的自身免疫性葡萄膜脑膜炎综合征。与对照组相比，VKH患者脑脊液中的CXCL10/IP-10和脑脊液中的CCL17/TARC显著升高。在大多数VKH病例和对照组中，脑脊液中的CXCL10高于血清中的CXCL10，而脑脊液中的CCL17低于血清中的CCL17。各组之间CCL11/嗜酸性粒细胞趋化因子无差异。VKH患者脑脊液中的CCL2/MCP-1显著低于对照组。VKH的变化与多发性硬化症（一种已知的以Th1为主的疾病）的变化基本相似。