人嗜T淋巴细胞病毒I型相关脊髓病中的脑脊液趋化因子：CXCL10上调及α干扰素的治疗作用
CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-alpha.
作者信息
Narikawa Koichi, Fujihara Kazuo, Misu Tatsuro, Feng Juan, Fujimori Juichi, Nakashima Ichiro, Miyazawa Isabelle, Saito Hiroshi, Sato Shigeru, Itoyama Yasuto
机构信息
Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan.
出版信息
J Neuroimmunol. 2005 Feb;159(1-2):177-82. doi: 10.1016/j.jneuroim.2004.10.011. Epub 2004 Dec 15.
We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-alpha therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.
我们采用酶联免疫吸附测定法（ELISA）检测了I型人类嗜T淋巴细胞病毒（HTLV-I）相关脊髓病/热带痉挛性截瘫（HAM/TSP）患者脑脊液（CSF）中的四种趋化因子。与对照组相比，T辅助细胞1型（Th1）相关趋化因子CXCL10/IP-10在HAM/TSP患者中显著升高，且其值在HAM/TSP患者中甚至比先前报道有CXCL10/IP-10上调的多发性硬化症（MS）患者还要高。在Th2相关趋化因子中，HAM/TSP患者的CCL17/TARC和CCL11/嗜酸性粒细胞趋化因子与对照组无差异。如在MS中所示，HAM/TSP患者的CCL2/单核细胞趋化蛋白-1（MCP-1）显著低于对照组。在HAM/TSP患者接受α干扰素治疗后，CCL2/MCP-1显著高于治疗前，这可能反映了Th2诱导，而CXCL10/IP-10仍保持升高。
Zotero 插件