SLAM/CD2基因簇广泛多态性与小鼠狼疮的关联。
Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.
作者信息
Wandstrat Amy E, Nguyen Charles, Limaye Nisha, Chan Alice Y, Subramanian Srividya, Tian Xiang-Hong, Yim Young-Sun, Pertsemlidis Alexander, Garner Harold R, Morel Laurence, Wakeland Edward K
机构信息
Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
出版信息
Immunity. 2004 Dec;21(6):769-80. doi: 10.1016/j.immuni.2004.10.009.
Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mice. T lymphocytes from B6.Sle1b mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes.
B6.Sle1b小鼠对自身免疫的易感性与SLAM/CD2基因家族两个不同单倍型之间的广泛多态性有关。在许多其他实验室小鼠品系中都发现了源自B6.Sle1b的SLAM/CD2家族单倍型，但只有在C57Bl/6（B6）基因组背景下才会引发自身免疫。表型分析揭示了B6.Sle1b小鼠T和B淋巴细胞中SLAM/CD2家族几个成员的结构和表达存在差异。B6.Sle1b小鼠的T淋巴细胞在4至6周龄时对刺激的信号反应发生了改变。虽然自身免疫可能由SLAM/CD2家族簇中的基因组合介导，但最有力的候选基因是Ly108，其一种特定的异构体在B6.Sle1b淋巴细胞中持续上调。
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