环境一氧化碳可能会影响冠状动脉疾病患者的心率变异性。
Ambient carbon monoxide may influence heart rate variability in subjects with coronary artery disease.
作者信息
Dales Robert
机构信息
HECSB/SEP/ECB/AHED/AQHER, Ottawa, Health Canada Air Quality-Health Effects Research Section, Health Canada, 275 Slater Street, 7th Floor, Ottawa, Ontario, Canada K1A 0L2.
出版信息
J Occup Environ Med. 2004 Dec;46(12):1217-21.
OBJECTIVE
Days of high ambient carbon dioxide (CO) have been associated with increased hospital admissions for cardiac disease. This study was conducted to determine if daily concentrations of CO and fine particulates (PM2.5) are associated with daily changes in heart rate variability.
METHODS
Each of 36 adults with coronary artery disease had personal exposure to PM2.5 and CO measured along with heart rate variability for one 24-hour period each week for up to 10 weeks.
RESULTS
Among those not taking beta-receptor blockers, there was a positive association between the standard deviation of the R-to-R intervals and CO (P = 0.02). No effect was found for PM2.5.
CONCLUSIONS
Urban exposure to CO may exert a biologic effect on the heart, which may be modified by medications.
目的
环境空气中高浓度二氧化碳（CO）的天数与心脏病住院人数增加有关。本研究旨在确定每日CO浓度和细颗粒物（PM2.5）是否与心率变异性的每日变化有关。
方法
36名患有冠状动脉疾病的成年人每人每周有一个24小时时间段进行个人PM2.5和CO暴露测量以及心率变异性测量，最长持续10周。
结果
在未服用β受体阻滞剂的人群中，R-R间期标准差与CO之间存在正相关（P = 0.02）。未发现PM2.5有影响。
结论
城市环境中的CO暴露可能对心脏产生生物学效应，这种效应可能会因药物而改变。
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