Worda Christof, Leipold Heinz, Gruber Christian, Kautzky-Willer Alexandra, Knöfler Martin, Bancher-Todesca Dagmar
Department of Obstetrics and Gynaecology, University of Vienna Medical School, Vienna General Hospital, Waehringer Guertel 18-20, A-1090 Vienna/Austria.
Am J Obstet Gynecol. 2004 Dec;191(6):2120-4. doi: 10.1016/j.ajog.2004.04.038.
Adiponectin is an adipocyte-specific protein that has been found to be associated with insulin sensitivity and obesity. Because gestational diabetes mellitus is associated with obesity and decreased insulin sensitivity, we have analyzed plasma adiponectin levels in women with gestational diabetes mellitus.
Twenty women with gestational diabetes mellitus and 21 unaffected women were included in the study. Plasma adiponectin levels were analyzed with the use of enzyme-linked immunosorbent assay.
Women with gestational diabetes mellitus were significantly older (34.3 years vs 29.4 years; P < .001) than unaffected women. Adiponectin plasma levels were significantly lower in women with gestational diabetes mellitus when compared with women without gestational diabetes mellitus (5827 +/- 1988 ng/mL vs 8085 +/- 3816 ng/mL; P = .02). Adiponectin plasma levels were correlated negatively with plasma glucose concentrations of the oral glucose tolerance test ( r > -0.38; P < .04) and correlated positively with gestational age ( r = 0.36; P = .03).
Our data show that decreased plasma adiponectin levels were found in women with gestational diabetes mellitus compared with unaffected women.
脂联素是一种脂肪细胞特异性蛋白，已发现其与胰岛素敏感性和肥胖有关。由于妊娠期糖尿病与肥胖及胰岛素敏感性降低相关，我们分析了妊娠期糖尿病女性的血浆脂联素水平。
本研究纳入了20名妊娠期糖尿病女性和21名未受影响的女性。采用酶联免疫吸附测定法分析血浆脂联素水平。
妊娠期糖尿病女性的年龄显著大于未受影响的女性（34.3岁对29.4岁；P < .001）。与未患妊娠期糖尿病的女性相比，妊娠期糖尿病女性的血浆脂联素水平显著降低（5827 ± 1988 ng/mL对8085 ± 3816 ng/mL；P = .02）。血浆脂联素水平与口服葡萄糖耐量试验的血糖浓度呈负相关（r > -0.38；P < .04），与孕周呈正相关（r = 0.36；P = .03）。
我们的数据表明，与未受影响的女性相比，妊娠期糖尿病女性的血浆脂联素水平降低。
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