Kwon Kihwan, Jung Sang Hyuk, Choi Chulhee, Park Si-Hoon
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.
Int J Cardiol. 2005 Jun 8;101(3):385-90. doi: 10.1016/j.ijcard.2004.03.050.
Obesity is one of the well-known risk factors of vascular disorders; however, the molecular mechanisms underlying the association between the two remain undetermined. Previous studies have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, are reduced in obese subjects, and that this hypoadiponectinemia is associated with ischemic heart disease. In this study, we sought to identify the primary determinants of plasma adiponectin levels in healthy premenopausal women.
We analyzed the plasma adiponectin concentrations in age-matched healthy obese premenopausal women [n=37, body mass index (BMI)> or= 25 kg/m(2)] and in healthy nonobese premenopausal women (n = 23, BMI < 25 kg/m(2)). Visceral and subcutaneous fat (VCF and SCF) areas were determined by abdominal computed tomography (CT) scan. Plasma levels of adiponectin in obese subjects were lower than in nonobese subjects (3.24 +/- 1.08 vs. 4.90 +/- 2.06 ug/ml, P < 0.01). Significant, univariate inverse correlations were observed between adiponectin levels and visceral fat areas (r = -0.643, p < 0.001), subcutaneous fat areas (r = -0.407, p < 0.01), and hsCRP (r = -0.36, p = 0.007). Plasma levels of adiponectin correlated positively with insulin sensitivity [quantitative insulin sensitivity check index (QUICKI): r = 0.38, p = 0.005] and high-density lipoprotein (HDL) cholesterol (r = 0.44, p = 0.001), and negatively with low-density lipoprotein (LDL) cholesterol (r = -0.29, p = 0.028), triglyceride (r = -0.33, p = 0.013), and BMI (r = -0.48, p < 0.001). By multivariate analysis, only visceral fat areas affected adiponectin plasma levels (beta = -0.016, p < 0.05, R(2) = 0.504). Plasma levels of HDL cholesterol remained significantly correlated to plasma adiponectin concentrations in multivariate analysis (beta = 0.067, p < 0.05).
These results collectively indicate that plasma HDL cholesterol levels and visceral fat masses are independently associated with plasma adiponectin concentrations.
肥胖是血管疾病的知名危险因素之一；然而，两者之间关联的分子机制仍未明确。既往研究表明，肥胖受试者体内脂肪源性激素脂联素的血浆水平降低，且这种低脂联素血症与缺血性心脏病相关。在本研究中，我们试图确定健康绝经前女性血浆脂联素水平的主要决定因素。
我们分析了年龄匹配的健康肥胖绝经前女性（n = 37，体重指数（BMI）≥25 kg/m²）和健康非肥胖绝经前女性（n = 23，BMI < 25 kg/m²）的血浆脂联素浓度。通过腹部计算机断层扫描（CT）确定内脏和皮下脂肪（VCF和SCF）面积。肥胖受试者的血浆脂联素水平低于非肥胖受试者（3.24±1.08 vs. 4.90±2.06 μg/ml，P < 0.01）。脂联素水平与内脏脂肪面积（r = -0.643，p < 0.001）、皮下脂肪面积（r = -0.407，p < 0.01）和hsCRP（r = -0.36，p = 0.007）之间存在显著的单变量负相关。血浆脂联素水平与胰岛素敏感性[定量胰岛素敏感性检查指数（QUICKI）：r = 0.38，p = 0.005]和高密度脂蛋白（HDL）胆固醇（r = 0.44，p = 0.001）呈正相关，与低密度脂蛋白（LDL）胆固醇（r = -0.29，p = 0.028）、甘油三酯（r = -0.33，p = 0.013）和BMI（r = -0.48，p < 0.001）呈负相关。通过多变量分析，只有内脏脂肪面积影响脂联素血浆水平（β = -0.016，p < 0.05，R² = 0.504）。在多变量分析中，HDL胆固醇血浆水平与血浆脂联素浓度仍显著相关（β = 0.067，p < 0.05）。
这些结果共同表明，血浆HDL胆固醇水平和内脏脂肪量与血浆脂联素浓度独立相关。
