Retnakaran R, Hanley A J G, Raif N, Connelly P W, Sermer M, Zinman B
Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada.
Diabet Med. 2004 Apr;21(4):388-92. doi: 10.1111/j.1464-5491.2004.1151.x.
People of South Asian descent face an increased risk of Type 2 diabetes mellitus (DM) and coronary artery disease (CAD) compared with other ethnic groups. One candidate factor underlying this risk may be adiponectin, as circulating levels of this adipocyte-derived protein are reduced in both Type 2 DM and CAD. In a recent study, we assessed the relationship between adiponectin and gestational diabetes (GDM), a potential model of early events in the natural history of Type 2 DM. Here, we report the impact of ethnicity on plasma adiponectin concentration in that study.
A cross-sectional study was performed in 180 women undergoing oral glucose tolerance testing in late second or early third trimester to investigate the relationship between adiponectin and glucose tolerance in pregnancy. Based on self-reported ethnicity, participants were stratified into three groups: (i) Caucasian (n = 116), (ii) South Asian (n = 31), and (iii) Asian (n = 28).
Median adiponectin concentration was much lower in the South Asian group (9.7 micro g/ml) than in Caucasians (15.8 micro g/ml) or Asians (16.1 micro g/ml) (overall P < 0.0001). With adjustment for age, prepregnancy body mass index, weight gain in pregnancy, previous history of GDM, family history of DM, fasting insulin and glucose intolerance, mean adiponectin remained significantly lower among South Asians compared with either Caucasians (P < 0.0001) or Asians (P = 0.0034).
Women of South Asian descent exhibit significantly reduced plasma concentrations of adiponectin in pregnancy compared with Caucasian and Asian counterparts. This observation raises the possibility of hypoadiponectinaemia as a potential factor contributing to the increased risk of diabetes and cardiovascular disease in South Asians.
与其他种族群体相比，南亚裔人群患2型糖尿病（DM）和冠状动脉疾病（CAD）的风险更高。导致这种风险的一个潜在因素可能是脂联素，因为在2型糖尿病和CAD患者中，这种脂肪细胞衍生蛋白的循环水平均降低。在最近的一项研究中，我们评估了脂联素与妊娠期糖尿病（GDM）之间的关系，GDM是2型糖尿病自然史早期事件的一个潜在模型。在此，我们报告该研究中种族对血浆脂联素浓度的影响。
对180名在孕中期晚期或孕晚期早期接受口服葡萄糖耐量试验的女性进行了一项横断面研究，以调查脂联素与妊娠期间葡萄糖耐量之间的关系。根据自我报告的种族，参与者被分为三组：（i）白种人（n = 116），（ii）南亚人（n = 31），和（iii）亚洲人（n = 28）。
南亚组的脂联素浓度中位数（9.7微克/毫升）远低于白种人（15.8微克/毫升）或亚洲人（16.1微克/毫升）（总体P < 0.0001）。在对年龄、孕前体重指数、孕期体重增加、既往GDM病史、DM家族史、空腹胰岛素和葡萄糖不耐受进行校正后，南亚人的平均脂联素水平仍显著低于白种人（P < 0.0001）或亚洲人（P = 0.0034）。
与白种人和亚洲女性相比，南亚裔女性在孕期血浆脂联素浓度显著降低。这一观察结果增加了低脂联素血症作为南亚人患糖尿病和心血管疾病风险增加的潜在因素的可能性。
