Corl Ammon B, Rodan Aylin R, Heberlein Ulrike
Department of Anatomy and Programs, University of California, San Francisco, California 94143-2822, USA.
Nat Neurosci. 2005 Jan;8(1):18-9. doi: 10.1038/nn1363. Epub 2004 Dec 12.
The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug.
胰岛素信号通路调节多种生理过程，包括能量代谢、机体生长、衰老和繁殖。我们在此表明，在果蝇中进行的基因操作若损害胰岛素产生细胞的功能或神经系统中胰岛素受体信号通路的功能，会导致对乙醇中毒作用的敏感性增加。这些发现表明，这一高度保守的通路在调节对成瘾性药物的行为反应方面具有此前未知的作用。
