German Cancer Research Center (Deutsches Krebsforschungszentrum), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
Biochem J. 2009 Dec 14;425(1):13-26. doi: 10.1042/BJ20091181.
The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and longevity. In the present review, I discuss the molecular mechanisms by which insulin signalling regulates metabolism in Drosophila, comparing and contrasting with the mammalian system. I discuss both the intracellular signalling network, as well as the communication between organs in the fly.
胰岛素信号通路在从哺乳动物到果蝇的生物中高度保守。在果蝇中，如在哺乳动物中一样，胰岛素信号调节许多生理功能，包括碳水化合物和脂质代谢、组织生长和寿命。在本综述中，我讨论了胰岛素信号调节果蝇代谢的分子机制，将其与哺乳动物系统进行了比较和对比。我讨论了细胞内信号网络，以及果蝇中器官之间的通讯。
