Simardi Lucila Heloisa, Tobias-MacHado Marcos, Kappaz Guilherme Tommasi, Taschner Goldenstein Patricia, Potts Jeannette M, Wroclawski Eric Roger
Department of Pathology, Faculdade de Medicina do ABC, Santo Andre, Sao Paulo, Brazil.
Urology. 2004 Dec;64(6):1098-101. doi: 10.1016/j.urology.2004.08.060.
To determine the influence of asymptomatic inflammatory processes of the prostate on serum prostate-specific antigen (PSA) levels.
A total of 51 patients with no evidence of prostate cancer or clinical prostatitis were prospectively studied. All subjects underwent 10 to 12 sector transrectal-ultrasound guided needle biopsies of the prostate. Serum PSA was measured 10 minutes before the biopsies. The fragments were stained and histologically analyzed. Two different classifications were used. One divided patients according to the number of specimens with inflammatory processes: 20% or less (group 1), more than 20% to 50% or less (group 2), and greater than 50% (group 3). Any kind of inflammatory process was considered positive. The second was the presence or absence of foreign body-type giant cells. Pearson's nonparametric test was used in the statistical analysis, with P <0.05 considered statistically significant.
The number of specimens with an inflammatory process was statistically significant (P = 0.02), with a median PSA level of 4.96 ng/mL in group 1 patients, 7.40 ng/mL in group 2, and 8.03 ng/mL in group 3 patients. The presence of foreign body-type giant cells in the histologic analysis was not statistically significant, with a median PSA level of 10.21 ng/mL compared with 5.89 ng/mL in the group without these cells.
The extension of the inflammatory process, as evaluated by the number of specimens involved, was directly related to elevations of serum PSA levels in asymptomatic patients. We could not find a statistically significant relationship between the presence of foreign body-type giant cells and serum PSA levels.
确定前列腺无症状性炎症过程对血清前列腺特异性抗原（PSA）水平的影响。
前瞻性研究了51例无前列腺癌或临床前列腺炎证据的患者。所有受试者均接受经直肠超声引导下的前列腺10至12个扇区穿刺活检。在活检前10分钟测量血清PSA。对活检组织进行染色并进行组织学分析。采用了两种不同的分类方法。一种根据有炎症过程的标本数量对患者进行分组：20%或更少（第1组）、超过20%至50%或更少（第2组）、大于50%（第3组）。任何类型的炎症过程均视为阳性。第二种是根据是否存在异物型巨细胞进行分类。统计分析采用Pearson非参数检验，P<0.05被认为具有统计学意义。
有炎症过程的标本数量具有统计学意义（P = 0.02），第1组患者的PSA中位数水平为4.96 ng/mL，第2组为7.40 ng/mL，第3组患者为8.03 ng/mL。组织学分析中异物型巨细胞的存在无统计学意义，有这些细胞组的PSA中位数水平为10.21 ng/mL，无这些细胞组为5.89 ng/mL。
通过受累标本数量评估的炎症过程范围与无症状患者血清PSA水平升高直接相关。我们未发现异物型巨细胞的存在与血清PSA水平之间存在统计学意义上的关系。
