Mosimann U P, Mather G, Wesnes K A, O'Brien J T, Burn D J, McKeith I G
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK.
Neurology. 2004 Dec 14;63(11):2091-6. doi: 10.1212/01.wnl.0000145764.70698.4e.
To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD).
The authors used a cross-sectional study to compare three demented groups matched for overall dementia severity (PDD: n = 24; DLB: n = 20; AD: n = 23) and two age-, sex-, and education-matched control groups (PD: n = 24, normal controls [NC]: n = 25).
Visual perception was globally more impaired in PDD than in nondemented controls (NC, PD), but was not different from DLB. Compared to AD, PDD patients tended to perform worse in all perceptual scores. Visual perception of patients with PDD/DLB and visual hallucinations was significantly worse than in patients without hallucinations.
Parkinson disease dementia (PDD) is associated with profound visuoperceptual impairments similar to dementia with Lewy bodies (DLB) but different from Alzheimer disease. These findings are consistent with previous neuroimaging studies reporting hypoactivity in cortical areas involved in visual processing in PDD and DLB.
量化帕金森病痴呆（PDD）、路易体痴呆（DLB）和阿尔茨海默病（AD）患者的视觉辨别、空间运动和物体形状感知能力。
作者采用横断面研究，比较三组痴呆严重程度总体匹配的患者（PDD：n = 24；DLB：n = 20；AD：n = 23）以及两组年龄、性别和教育程度匹配的对照组（PD：n = 24，正常对照组[NC]：n = 25）。
PDD患者的整体视觉感知能力比非痴呆对照组（NC、PD）受损更严重，但与DLB无差异。与AD相比，PDD患者在所有感知评分上往往表现更差。有视觉幻觉的PDD/DLB患者的视觉感知明显比无幻觉患者差。
帕金森病痴呆（PDD）与严重的视觉感知障碍有关，类似于路易体痴呆（DLB），但与阿尔茨海默病不同。这些发现与之前的神经影像学研究一致，该研究报告PDD和DLB中参与视觉处理的皮质区域活动减退。
