酵母水解物可降低饮食诱导肥胖大鼠的体脂。

Yeast hydrolysate reduces body fat of dietary obese rats.

作者信息

Kim K M, Chang U J, Kang D H, Kim J M, Choi Y M, Suh H J

机构信息

Department of Food and Nutrition, College of Health Sciences, Korea University, 1 Jeongneung-dong, Sungbuk-ku, Seoul 136-703, Korea.

出版信息

Phytother Res. 2004 Nov;18(11):950-3. doi: 10.1002/ptr.1582.

DOI:10.1002/ptr.1582

PMID:15597316

Abstract

The purpose of this study was to assess the antiobesity effect of the yeast hydrolysate (DNF) on the body weight, body fat and plasma lipids levels of high-fat fed rats. The weight gain of the HF (high fat diet) (162.58 +/- 6.68 g) was significantly (p < 0.05) greater than that of DNF-1, DNF-2, (high fat diet with DNF of 0.5 and 1.0 g/kg body weight, respectively) and control groups (143.19 +/- 7.33 g, 139.20 +/- 8.36 g, 130.23 +/- 8.02 g, respectively). The wet weight of the epididymal fat and the perirenal fat pads of the DNF-1, DNF-2 and control groups were reduced significantly (p < 0.05). A significant (p < 0.05) increase of HDL-cholesterol level of the DNF-2 and control groups was observed. However, there was no significant difference between DNF-1 and DNF-2. It was also found that the triacylglycerol (TG) levels decreased significantly (p < 0.05) in the DNF-2 group from that of the HF, but there was no significant (p < 0.05) difference between DNF-1 and DNF-2.

摘要

本研究的目的是评估酵母水解物（DNF）对高脂喂养大鼠体重、体脂和血浆脂质水平的抗肥胖作用。高脂饮食（HF）组（162.58±6.68克）的体重增加显著（p<0.05）高于DNF-1组、DNF-2组（分别为高脂饮食添加0.5克/千克体重和1.0克/千克体重的DNF）以及对照组（分别为143.19±7.33克、139.20±8.36克、130.23±8.02克）。DNF-1组、DNF-2组和对照组的附睾脂肪和肾周脂肪垫湿重显著降低（p<0.05）。观察到DNF-2组和对照组的高密度脂蛋白胆固醇水平显著升高（p<0.05）。然而，DNF-1组和DNF-2组之间没有显著差异。还发现，DNF-2组的三酰甘油（TG）水平比高脂饮食组显著降低（p<0.05），但DNF-1组和DNF-2组之间没有显著差异（p<0.05）。