Reference values for clinical chemistry and clinical hematology parameters in cynomolgus monkeys.

BACKGROUND

In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required.

METHODS

These values are available from baseline levels in animals subjected to tolerability/pharmacokinetic studies. For each individual study two tests for clinical chemistry and hematology were performed before the start of treatment.

RESULTS AND CONCLUSION

Baseline levels were determined in 27 males and 15 females, in total 106 determinations (53 in males, and 53 in females). For a number of parameters levels in cynomolgus monkeys show clear differences from those in baboons. These data are reported here to provide baseline values for veterinarians and investigators using nonhuman primates in experimental studies.