van der Hem P S, Nauta J M, van der Wal J E, Roodenburg J L N
Department of Oral and Maxillofacial Surgery, Groningen University Hospital, P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Oral Oncol. 2005 Jan;41(1):31-7. doi: 10.1016/j.oraloncology.2004.06.010.
Oral leukoplakia is an important premalignant lesion of the oral mucosa. We treat this lesion prophylactically with CO2 laser evaporation. In the period from 1976 to 2001, a group of 200 patients with 282 oral leukoplakias were treated by CO2 laser evaporation. In a follow up period of 1-219 months (mean 52), 251 treated leukoplakias (89.0%) did not show a recurrence. Twenty eight (9.9%) local recurrences were observed in 5 to 168 months after treatment. Three (1.1%) squamous cell carcinoma, occurred in the treated area respectively 7, 17 and 19 month after CO2 laser evaporation. This large study with a long follow up shows that laser treatment is a good prophylactic treatment for oral leukoplakia.
口腔白斑是口腔黏膜一种重要的癌前病变。我们采用二氧化碳激光汽化术对该病变进行预防性治疗。在1976年至2001年期间，一组200例患有282处口腔白斑的患者接受了二氧化碳激光汽化术治疗。在1至219个月（平均52个月）的随访期内，251处接受治疗的白斑（89.0%）未出现复发。治疗后5至168个月观察到28处（9.9%）局部复发。3例（1.1%）鳞状细胞癌分别在二氧化碳激光汽化术后7、17和19个月出现在治疗区域。这项长期随访的大型研究表明，激光治疗是口腔白斑的一种良好预防性治疗方法。
