Med Lett Drugs Ther. 2005 Jan 3;47(1199):1-3.
Acamprosate has a different mechanism of action than other drugs used for maintenance of abstinence from alcohol and is generally well tolerated. Diarrhea is the most common adverse effect. Its efficacy in controlled trials has been modest at best, and was poor when patients lacked social support for remaining abstinent. Acomprosate can be used in combination with naltrexone or disulfiram.
阿坎酸的作用机制与用于维持戒酒的其他药物不同,且一般耐受性良好。腹泻是最常见的不良反应。在对照试验中,其疗效充其量只能说是一般,而且当患者缺乏保持戒酒的社会支持时效果很差。阿坎酸可与纳曲酮或双硫仑联合使用。