Yanaga Hiroko, Koga Mika, Imai Keisuke, Yanaga Katsu
Yanaga Clinic and Tissue Culture Laboratory, 1-4-6, Kumamoto, Kokura-Kita-Ku, Kitakyushu, Fukuoka 802-0044. Japan,
Aesthetic Plast Surg. 2004 Jul-Aug;28(4):212-21. doi: 10.1007/s00266-004-3092-8.
A new method of nasal augmentation has been developed, in which cultured autologous chondrocytes are transplanted. Using biotechnology, a piece of the choncha cartilage 1 cm2 is cultured into a gel-type mass of chondrocytes, which then is transplanted by injection into a surgically created subperiosteal skin pocket on the nasal dorsum. The augmented nose is taped and protected for 1 week. The grafted chondrocytes develop into mature cartilaginous tissue after approximately 1 month. This method was used in eight cases of nasal augmentation, and one case of chin augmentation (performed simultaneously), and one case of depressed deformity on the forehead. The results obtained by this method to date have been satisfactory after a follow-up time of 6 to 24 months. The authors believe that this method may at least partially be able to replace silicone implantation for nasal augmentation.
一种新的隆鼻方法已经研发出来，即移植培养的自体软骨细胞。利用生物技术，将1平方厘米的鼻甲软骨培养成凝胶状的软骨细胞团块，然后通过注射将其移植到在鼻背手术创建的骨膜下皮袋中。隆鼻后用胶带固定并保护1周。移植的软骨细胞大约1个月后发育成成熟的软骨组织。该方法用于8例隆鼻、1例同时进行的隆颏以及1例前额凹陷畸形修复。经过6至24个月的随访，迄今为止该方法取得的效果令人满意。作者认为，这种方法至少可以部分替代硅胶植入隆鼻。
