Del Arco A, Mora F
Department of Physiology, Faculty of Medicine, Universidad Complutense, Madrid, Spain.
J Neural Transm (Vienna). 2005 Jan;112(1):97-109. doi: 10.1007/s00702-004-0172-5. Epub 2004 Jun 18.
In the context of the in vivo neurochemical literature this article reviews some recent microdialysis studies in our laboratory of glutamate-dopamine interaction in the prefrontal cortex (PFC) and its possible role in modulating dopamine and acetylcholine release in the nucleus accumbens. A functional glutamate-dopamine interaction in PFC has been reported by microdialysis studies showing that both stimulation and blockade of prefrontal glutamate receptors produce changes of basal and/or stimulated release of dopamine in this area of the brain. These studies suggest that dopamine function in PFC is modulated locally by prefrontal glutamatergic inputs and that glutamate and dopamine can act simultaneously to regulate GABA release in PFC. In particular, dopamine can enhance the increases of extracellular GABA produced by the stimulation of prefrontal glutamate receptors. We report also that the stimulation of prefrontal D2 and mGluI receptors and their interaction changes the release of dopamine and acetylcholine in the nucleus accumbens.
在体内神经化学文献的背景下，本文回顾了我们实验室最近关于前额叶皮质（PFC）中谷氨酸 - 多巴胺相互作用及其在调节伏隔核中多巴胺和乙酰胆碱释放方面可能作用的一些微透析研究。微透析研究报告了PFC中存在功能性谷氨酸 - 多巴胺相互作用，表明前额叶谷氨酸受体的刺激和阻断都会导致该脑区基础和/或刺激诱导的多巴胺释放发生变化。这些研究表明，PFC中的多巴胺功能受前额叶谷氨酸能输入的局部调节，并且谷氨酸和多巴胺可以同时作用以调节PFC中的GABA释放。特别是，多巴胺可以增强前额叶谷氨酸受体刺激所产生的细胞外GABA的增加。我们还报告说，前额叶D2和mGluI受体的刺激及其相互作用会改变伏隔核中多巴胺和乙酰胆碱的释放。
