Bargon Joachim, Müller Ulrike, Buhl Roland
St. Elisabethen-Krankenhaus, Frankfurt/Main.
Med Klin (Munich). 2004 Dec 15;99(12):719-26. doi: 10.1007/s00063-004-1106-6.
Within the last few years our knowledge concerning the pathogenesis of chronic obstructive pulmonary disease (COPD) has grown. We now know that COPD is not simply a lung disease but a type of systemic disease. The systemic inflammation which can be found in COPD and the oxidant burden lead to systemic changes in muscles, endocrinium, bones, and blood vessels. Patients with COPD are often undernourished and have a low muscle mass even if the body mass is normal.
Loss of muscle mass, caused by different mechanisms, influences the muscle endurance of COPD patients. Weight loss as well as loss of muscle mass are negatively correlated with morbidity and mortality of these patients.
Nutritional support like dietary advice, including supplements especially in combination with exercise, which could improve the quality of life of these patients, are approaches which are not sufficiently considered in the treatment of COPD.
在过去几年中，我们对慢性阻塞性肺疾病（COPD）发病机制的认识有所增加。我们现在知道，COPD不仅仅是一种肺部疾病，而是一种全身性疾病。在COPD中发现的全身炎症和氧化应激负担会导致肌肉、内分泌、骨骼和血管的全身性变化。即使体重正常，COPD患者也常常营养不良且肌肉量较低。
由不同机制引起的肌肉量减少会影响COPD患者的肌肉耐力。体重减轻以及肌肉量减少与这些患者的发病率和死亡率呈负相关。
营养支持，如饮食建议，包括补充剂，尤其是与运动相结合，这可能改善这些患者的生活质量，但在COPD治疗中并未得到充分考虑。
